Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, leading to pain and stiffness. Over time, it can cause the vertebrae in the spine to fuse, resulting in reduced flexibility and a hunched posture. While AS most commonly affects the lower back, it can also impact other joints, the eyes, and, in rare cases, organs like the heart and lungs. The exact cause of AS is unknown, but genetic factors, particularly the HLA-B27 gene,
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